17TH MONA SYMPOSIUM - JANUARY 5 - 9, 1998

• Visiting Participants
• Plenary Lectures
• Daily Schedule

MONDAY, JANUARY 5
Morning

10:00 - 11:00 Andrew G. Myers
Division of Chemistry and Chemical Engineering
California Institute of Technology
1201 East California Boulevard
Pasadena, CA 91125
U S A

TITLE: New Strategies for the Construction of the Enediyne Antibiotics.
Synthesis of the Antitumor Agent Neocarzinostatin Chromophore.

11:10 - 12:10 Tom J. Mabry
Department of Botany
The University of Texas at Austin
Austin, TX 78713-76460
U S A

TITLE: Nonprotein Amino Acids and Azoxyglycosides from Cycads

Afternoon

2:00 - 3:00 Dale Poulter
Department of Chemistry
University of Utah
Salt Lake City, UT 84112
U S A

TITLE: Biosynthesis of Non-Head-to-Tail Isoprenoids. Controlling Unruly Substrates.

TUESDAY, JANUARY 6
Morning

9:00 - 10:00 Donald Craig
Department of Chemistry
Imperial College of Science
Technology and Medicine
London, UK SW7 1AY

TITLE: Cyclisation and cycloaddition-based Approaches for the Synthesis of Natural Products.

10:25 - 11:25 Susumi Hatakeyama
Faculty of Pharmaceutical Sciences
Nagasaki University
1-14 Bunkyuo-cho
Nagasaki, Japan 852

TITLE: Allenylmethylsilanes and Their Utilisation for Natural Product Synthesis

Afternoon

2:15 - 3:15 Peter Wipf
Department of Chemistry
University of Pittsburgh
Pittsburgh, PA
U S A

TITLE: Synthetic Studies of Azole Natural Products.

THURSDAY, JANUARY 8

Morning
9:00 - 10:00 David R. Mootoo
Department of Chemistry
Hunter College
695 Park Avenue
New York City
NY 10021
U S A

TITLE: Synthesis of C-Glycosides via Oxocarbenium Ion Cyclizations.

10:30 - 11:30 Rawle I. Hollingsworth
Departments of Chemistry and Biochemistry
Michigan State University
East Lansing, MI 48824
U S A

TITLE: Carbohydrates as a Chiral Feedstock Approach: A General Route to Chirality.

Afternoon

2:00 - 3:00 Richard C A Isaacs
Department of Medicinal Chemistry
Merck Research Laboratories
Merck and Co. Inc.
P.O. Box 4, WP 26-410
West Point 4, PA 19486
U S A

TITLE: Recent Progress in the Development of Orally Active Nonpeptidic Thrombin Inhibitors.
 
FRIDAY, JANUARY 9
 
Morning
9:00 - 10:00 Stuart J. Rowan
University Chemical Laboratory
University of Cambridge
Lensfield Road
Cambridge, UK CB2 1EW

TITLE: Unnatural Things with Natural Products.
 
10:30 - 11:30 Joe Connolly
Department of Chemistry
University of Glasgow
Glasgow
Scotland, UK G12 8QQ
;
TITLE: Natural Products from Around the World.
back to top

MONDAY, JANUARY 5
Morning

8:00 - 8:30 Completion of Registration

8:30 - 9:30 Opening Ceremony and Announcements.

Chairman: Prof W. R. Chan

9:30 - 10:00 Coffee Break

10:00 - 11:00 Plenary Lecture

Andrew G. Myers - New Strategies for the Construction of
the Enediyne Antibiotics. Synthesis of the Antitumor Agent
Neocarzinostatin Chromophore.

11:00 - 11:10 Question and Discussion Period.

11:10 - 12:10 Plenary Lecture
Tom J. Mabry - Nonprotein Amino Acids and
Azoxyglycosides from Cycads.
 
12:10 - 12:20 Question and Discussion Period.

Afternoon

Chairman: Prof Stewart McLean

2:00 - 3:00 Plenary Lecture
Dale Poulter - Biosynthesis of Non-Head-to-Tail Isoprenoids
Controlling Unruly Substrates

3:00 - 3:10 Question and Discussion Period.

3:10 - 3:30 Paper #1
Bernard J. Rawlings, C.M. McNamara, S. Box, J.M. Crawforth, B.S. Hickman and T.J. Norwood - Biosynthesis
of Amphotericin B.

3:30 - 3:45 Coffee Break

3:45 - 4:05 Paper #2
William F. Reynolds - Choosing the Optimum Combinations
of NMR Experiments and Processing Parameters for Natural
Products Structure Elucidation.

4:05 - 4:25 Paper #3
Sonia Peter, W.F. Tinto and W.F. Reynolds - Cassanes,
Including a Rearranged Furanoditerpene.

4:25 - 4:55 Paper #4
Wolfgang Kraus - Bioassay Guided Isolation of Bioactive
Compounds from Plant Extracts.

4:45 - 4:55 Question and Discussion Period.

back to top

TUESDAY, JANUARY 6
Morning
Chairman: Prof Richard W. Franck

9:00 - 10:00 Plenary Lecture
Donald Craig - Cyclisation and Cyclo-addition-based
Approaches for the Synthesis of Natural Products.

10:00 - 10:10 Question and Discussion Period.

10:10 - 10:25 Coffee Break

10:25 - 11:25 Plenary Lecture
Susumi Hatakeyama - Allenylmethylsilanes and their
Utilisation for Natural Product Synthesis.

11:25 - 11:35 Question and Discussion Period.

11:35 - 11:55 Paper #5
Michael Thomas, C.J. Suckling, A.R. Pitt and K.E. Suckling -
The Synthesis and Evaluation of Cholesterol Derivatives.

11:55 - 12:15 Paper #6
Raul G. Enriquez, W.F. Reynolds, B. Ortiz, E. Alducin,
D. Gnecco and M.L. Villarreal - Chemical Transformations of
Secondary Metabolites in Search for Bioactive Compounds,
Promising Derivatives of Perozone.

12:15 - 12:25 Question and Discussion Period.

Afternoon

Chairman: Prof G. Davon Kennedy
2:15 - 3:15 Plenary Lecture
Peter Wipf - Synthetic Studies of Azole Natural Products.

3:15 - 3:25 Question and Discussion Period.

3:25 - 3:40 Coffee Break

3:40 - 4:00 Paper #7
Mohammad Behforouz - Synthesis and Antitumor Studies of
Lavendamycins

4:00 - 4:20 Paper #8
James Cook, Jin Li and P. Yu - Enantiospecific Total Synthesis of (+)-Ajmaline, Talpinine, Talcarpine and Alkaloid G via The Asymmetric Pictet-Spengler Reaction.

4:20 - 4:30 Question and Discussion Period.

back to top

THURSDAY, JANUARY 8
Morning

Chairman: Prof James Cook

9:00 - 10:00 Plenary Lecture
David R. Mootoo - Synthesis of C-Glycosides via
Oxocarbenium Ion Cyclizations.

10:00 - 10:10 Question and Discussion Period.

10:10 - 10:25 Coffee Break

10:25 - 11:25 Plenary Lecture
Rawle I. Hollingsworth - Carbohydrates as a Chiral
Feedstock Approach: A General Route to Chirality.

11:25 - 11:35 Question and Discussion Period.

11:35 - 11:55 Paper #9
Richard W. Franck and P. Belica - C-Glycosides via the
Ramberg-Backlund Reaction.

11:55 - 12:15 Paper #10
John W. Huffman and Shu Yu - Synthesis and Pharmacology
of 1-Deoxy Cannabinoids.

12:15 - 12:25 Question and Discussion Period.

Afternoon

Chairman: Prof John Huffman
2:00 - 3:00 Plenary Lecture
Richard C.A. Isaacs - Recent Progress in the Development of
Orally Active Nonpeptidic Thrombin Inhibitors.

3:00 - 3:10 Question and Discussion Period.

3:10 - 3:25 Coffee Break

3:25 - 3:45 Paper #11
William N. Setzer - Phytochemical Investigation of a Salacia
Liana Species from Monteverde Costa Rica.

3:45 - 4:05 Paper #12

Sophia Edwards, S. Song and D.W. Dixon - Anthraquinones
as DNA Threading Intercalators and DNA Cleaving Agents.

4:05 - 4:25 Paper #13

Keshore R. Bidasee, J.A. Coles, J.S. Rastegar and H.R. Besch Jr. -
Understanding Cardiac Contractility: Plant Alkaloid Ryanodine.

4:25 - 4:35 Question and Discussion Period.

back to top

FRIDAY, JANUARY 9
Morning

Chairman: Prof Baldwin Mootoo
9:00 - 10:00 Plenary Lecture

Stuart J. Rowan - Unnatural Things with Natural Products.
10:00 - 10:10 Question and Discussion Period.

10:10 - 10:30 Coffee Break

10:30 - 11:30 Plenary Lecture
Joe Connolly - Natural Products from Around the World

11:30 - 11:40 Question and Discussion Period.

11:40 - 12:00 Closing Ceremony.

back to top

Participants: (P)= Plenary Speaker

click for larger image from the 1998 Symposium

Return to Chemistry, UWI-Mona, Home Page