SCIENTIFIC PROGRAMME
PLENARY LECTURES
MONDAY, JANUARY 8
Morning
10:00 - 11:00 David G.I. Kingston
Department of Chemistry
Virginia Tech
Blacksburg, VA 24061-0212
U S A
TITLE: Fun and Games with Taxol: New and Old Reactions of
a Complex Natural Product.
11:10 - 12:10 Chris Abell
Department of Chemistry
University of Cambridge
Lensfield Road
Cambridge CB2 1EW
England
TITLE: Mechanistic Studies on Biosynthetic Enzymes
Afternoon
2:00 - 3:00 J -L. Wolfender
Institut De Pharmacognosie et
Phytochimie
University of Lausanne
BEO. CH-1915
Lausanne
Switzerland
TITLE: Strategies in the Search for New Bioactive Plant
Constituents.
TUESDAY, JANUARY 9
Morning
9:00 - 10:00 William F. Reynolds
Department of Chemistry
University of Toronto
Toronto, Ontario
Canada M5S 1A1
TITLE: Multi-Dimensional NMR Studies of Natural and Synthetic
Products
10:25 - 11:25 Mugio Nishizawa
Faculty of Pharmaceutical Sciences
Tokushima Bunri University
Tamashiro-cho, Tokushima 770
Japan
TITLE: Synthetic Approaches into Intensely Sweet Glycosides,
Baiyunoside and Osladin.
Afternoon
2:15 - 3:15 Paul L. Feldman
Glaxo Wellcome
Five Moore Drive
Research Triangle Park
N C 27709
U S A
TITLE: Organic Chemistry Aiding Basic Biological Research:
Understanding Nitric Oxide Synthase.
THURSDAY, JANUARY 11
Morning
9:00 - 10:00 William Gerwick
College of Pharmacy
Oregon State University
Corvallis, OR 97331-3507
U S A
TITLE: Structure and Biosynthesis of Bioactive Lipopeptides
from Marine Blue-Green Algae.
10:30 - 11:30 George A. Ellestad
American Cyanamid Co.
Pearle River, N Y 10966
U S A
TITLE: Recent Studies on the Mechanism of Action of
Calicheamicin.
Afternoon
FRIDAY, JANUARY 12
Morning
9:00 - 10:00 Franz Oesch
Institute of Toxicology
University of Mainz
Obere Zahlbacher StraBe 67
D-6500 Mainz
Germany
TITLE: (TO BE ANNOUNCED)
10:30 - 11:30 Tom J. Simpson
Department of Chemistry
University of Bristol
Cantocks Close
Bristol BS8 1TS
United Kingdom
TITLE: Polyketide Chain Assembly - Problems and Solutions.
back to top
DAILY SCHEDULE
MONDAY, JANUARY 8
Morning
8:00 - 8:30 Completion of Registration
8:30 - 9:30 Opening Ceremony
9:30 - 9:40 Announcements
Chairman: Prof W R Chan
9:40 - 10:00 Coffee Break
10:00 - 11:00 Plenary Lecture
David G.I. Kingston - Fun and Games with
Taxol: New and Old Reactions of a Complex
Natural Product.
11:00 - 11:10 Question and Discussion Period
11:10 - 12:10 Chris Abell - Mechanistic Studies on
Biosynthetic Enzymes
12:10 - 12:20 Question and Discussion Period.
Afternoon
Chairman: Prof S McLean
2:00 - 3:00 Plenary Lecture
J -L. Wolfender - Strategies in the Search for
New Bioactive Plant Constituents
3:00 - 3:10 Question and Discussion Period.
3:10 - 3:30 Paper #1
*Kurt Wagschal, Y. Yoshizawa, D.J. Witter,
Y. Liu and J.C. Vederas - Biosynthesis of the
Hypocholesterolemic Polyketides ML-226C and
Compactin by Penicillum aurantiogriseum and
Lovastatin by Aspergillus terreus:
Determination of the Origin of Carbon,
Hydrogen and Oxygen Atoms by C13 NMR.
3:30 - 3:45 Coffee Break
3:45 - 4:05 Paper #2
Kuniaki Tatsuta - Total Synthesis and
Chemical Design of Useful Glycosidase
Inhibitors.
4:05 - 4:25 Paper #3
*Peter L. Ruddock and P.B. Reese - The Scope
and Limitations of the Reaction of
Mercury(II) Trifluoroacetate with D-Steriods.
Afternoon Cont'd
4:25 - 4:45 Paper #4
Philip Lowden - Studies on the Biosynthesis
of Rapamycin.
4:45 - 4:55 Paper #5
Const. Gletos - Rapamycin: An Extraordinary
Recovery from fermentation Broth.
4:55 - 5:05 Question and Discussion Period.
back to top
TUESDAY, JANUARY 9
Morning
Chairman: Dr Baldwin Mootoo
9:00 - 10:00 Plenary Lecture
William F Reynolds - Multi-Dimensional NMR
Studies of Natural and Synthetic Products.
10:00 - 10:10 Question and Discussion Period.
10:10 - 10:25 Coffee Break
10:25 - 11:25 Plenary Lecture
Mugio Nishizawa - Synthetic Approaches into
intensely Sweet Glycosides Baiyunoside and
Osladin.
11:25 - 11:35 Question and Discussion Period.
11:35 - 11:55 Paper #6
*Augusto Rodriquez, J. Gabriel Garcia,
T. Kaimari and J. Hass - Intramolecular
Reactions of [3]-Cumulenes.
11:55 - 12:15 Paper #7
*Michael A Lyon and Y. Jackson - The Synthesis
of Analogues of Kuanoniamine A.
12:15 - 12:25 Question and Discussion Period.
Afternoon
Chairman: Prof Kuniaki Tatsuta
2:15 - 3:15 Plenary Lecture
Paul L. Feldman - Organic Chemistry Aiding
Basic Biological Research: Understanding
Nitric Oxide Synthase.
3:15 - 3:25 Question and Discussion Period
3:25 - 3:40 Coffee Break
3:40 - 4:00 Paper #8
*James M. Cook and T. Gan - Studies Directed
Toward Enantiospecific Synthesis of the
Antiamoebic Alkaloid Macrocarpamine and
10-Methoxymacrocarpamine.
4:00 - 4:20 Paper #9
*Laszlo v. Szentpaly and I.L. Shamovsky -
Modelling Intercalated PAH Metabolites:
Explanation for the Stereochemical and Shape
Selectivity of B-DNA for Bay-Region
Carcinogens.
4:20 - 4:40 Paper #10
*Bernard J. Rawling and P.R. James - Probing
the Mechanism of Action of Amphotericin B.
4:40 - 5:00 Paper #11
*John W. Huffman and S. Yu - A Probe for the
Cannabinoid Receptor: Synthesis of Deoxy
HU-210.
5:00 - 5:10 Question and Discussion Period.
back to top
THURSDAY, JANUARY 11
Morning
Chairman: Prof. James Cook
9:00 - 10:00 Plenary Lecture
William Gerwick - Structure and Biosynthesis
of Bioactive Lipopeptides from Marine
Blue-Green Algae
10:00 - 10:10 Question and Discussion Period
10:10 - 10:25 Coffee Break
10:25 - 11:25 Plenary Lecture
George A. Ellestad - Recent Studies on the
Mechanism of Action of Calicheamicin.
11:25 - 11:35 Question and Discussion Period.
11:35 - 11:55 Paper #12
Annabel Cutter - Studies on the Biosynthesis
of Erythromycin.
11:55 - 12:15 Paper #13
12:15 - 12:35 Paper #14
Richard Franck - The Cycloaddition Way to
Glycosyl Transfer.
12:35 - 12:45 Question and Discussion Period.
Afternoon
Chairman: Prof Augusto Rodriquez
2:00 - 3:00 Plenary Lecture
K. Hostettmann - Strategies in the Search for
New Bioactive Plant Constituents
3:00 - 3:10 Question and Discussion Period
3:10 - 3:25 Coffee Break
3:25 - 3:45 Paper #15
Wolfgang Kraus - Biologically Active
Constituents of Tropical and Subtropical
Plants
3:45 - 4:05 Paper #16
*Roy B Porter and P.B. Reese - Secondary
Metabolites from Hyptis verticillata.
4:05 - 4:25 Paper #17
*Joanna M. Harris and J.C. Vederas - Synthesis
of Chiral Azodicarboxylate Esters and
Azodicarboxamides: Electrophilic Amination of
Achiral Enolates.
4:25 - 4:45 Paper #18
*Nicholas J. Lawrence and Simon W. Beeden -
2'-Desacetoxyaustropicatine from the Stem
Bark of Taxus Baccata: A Good Starting
Material for the Synthesis of Bioactive
Taxoids?
4:45 - 4:55 Question and Discussion Period.
back to top
FRIDAY, JANUARY 12
Morning
Chairman: Prof John Huffman
9:00 - 10:00 Plenary Lecture
Franz Oesch - (Title to be announced)
10:00 - 10:10 Question and Discussion Period
10:10 - 10:30 Coffee Break
10:30 - 11:30 Plenary Lecture
Tom J. Simpson - Polyketide Chain Assembly -
Problems and Solutions.
11:30 - 11:40 Question and Discussion Period
11:40 - 12:00 Closing Ceremony.
back to top
VISITING PARTICIPANTS
ABELL, C. HARRIS, J. NICELY, P.
BAMFORD, S. HOLDER, A. NISHIZAWA, M.
CHAN, W. HOLZBAUR, I. OESCH, F.
COOK, J. HOSTETTMANN, K. ONAKUNLE, O.A.
CONSTANTIN, B. HUFFMAN, J. PERRY, D.
CUTTER, A. JARRETT, S. RAWLINGS, B.
DANIEL, D. KINGSTON, D.G.I. REYNOLDS, W.F.
DRYSDALE, N. KRAUS, W. RODRIQUES, A.
DUCKI, S. LAWRENCE, N. SIMPSON, T.J.
ELLESTAD, A.E. LOWDEN, P. SUNDARAMOORTHI, R.
FELDMAN, P.L. MAXWELL, A. TATSUTA, K.
FLYNN, D.L. MCLEAN, S. TINTO, W.
FRANCK, R. MOOTOO, B. WAGSCHAL, K.
GERWICK, W. MORGAN, T. WILSON, D.
NEWTON, A.
Back to the top